Aspirus Regional Cancer Center

Cancer Clinical Trials

This is a current listing of active clinical trials at the Aspirus Regional Cancer Center. From this list you can select a specific cancer that you are interested in (for example, breast or colon cancer) and then review the clinical trials that are active at the Aspirus Regional Cancer Center for that specific disease.

Metastatic Pancreatic

Trial Name: Randomized Phase II Clinical Trial of AZD6244 Hydrogen Sulfate (NSC-748727 and MK-2206 (NSC-749607) vs. mFOLFOX in Patients with Metastatic Pancreatic Cancer after Prior Chemotherapy.

Protocol ID: S1115



  • Patients must have histologically or cytologically confirmed diagnosis of pancreatic adenocarcinoma.  Patients with endocrine or neuroendocrine tumors, lymphoma of the pancreas, or ampullary cancer are not eligible.
  • Patients must have distant metastatic disease. 
  • Patients must have received one line, and no more than one line, of prior gemcitabine chemotherapy for pancreatic cancer. 
  • Patient must not have received prior treatment with FOLFIRINOX, FOLFOX, MEK inhibitors, P13K inhibitors, or AKT inhibitors.
  • Patient must meet required laboratory values.
  • Patients must be able to swallow tablets and capsules.
  • No prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated Stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for five years.

Patients must not be pregnant or nursing due to unknown fetal and infant risks.  Women/men of reproductive potential must have agreed to use an effective contraceptive method during the study plus at least 6 months after last dose.

Enrollment: 133 Participants


Taking part in this study may or may not make your health better.  While doctors hope the study treatment will be more useful against cancer compared to the usual treatment, there is no proof of this yet.  We do know that the information from this study will help doctors learn more about these combinations of drugs as a treatment for cancer.  This information could help future cancer patients.


These clinical trial overviews are intended to provide a brief overview of the clinical trial. To help determine whether the trial is appropriate for you, the major eligibility criteria are listed above. To obtain more information on the eligibility and the treatment plan, please contact our Aspirus Regional Cancer Center Oncology Clinical Research Coordinator, Beth Knetter at 715-847-2353 or 1-800-283-2881, ext.72353, or Langlade Cancer Center Research Nurse Debra Witman @ 715-623-9587.

Created: Jul 19, 2013

Updated: May 21, 2014

« Return to Trials