Aprepitant (By injection)

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Aprepitant (ap-RE-pi-tant)

Prevents nausea and vomiting caused by chemotherapy (cancer medicine).

Brand Name(s)


There may be other brand names for this medicine.

When This Medicine Should Not Be Used

This medicine is not right for everyone. You should not receive it if you had an allergic reaction to aprepitant.

How to Use This Medicine


  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. This medicine must be given slowly, so the needle will have to stay in place for over 30 minutes. It will be given on the first day of your chemotherapy session, along with other medicines, about 30 minutes before the start of treatment.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • You should not receive this medicine together with pimozide.
  • Some medicines can affect how aprepitant works. Tell your doctor if you are using any of the following:
    • Carbamazepine, clarithromycin, dexamethasone, diltiazem, itraconazole, ketoconazole, methylprednisolone, nefazodone, nelfinavir, phenytoin, rifampin, ritonavir, troleandomycin
    • Blood thinner (including warfarin)
    • Cancer medicines (including ifosfamide, vinblastine, vincristine)
    • Sedative medicine (including alprazolam, midazolam, triazolam)

Warnings While Using This Medicine

  • Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease or blood clotting problems.
  • Birth control (including pills, rings, implants and other devices) may not work as well to prevent pregnancy when used with this medicine. Use another form of birth control that does not contain hormones (including condoms or spermicide) along with your pills. Use an effective form of birth control during treatment with this medicine and for 1 month after the last dose.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash

If you notice these less serious side effects, talk with your doctor:

  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088